0001 Effect of Time-Restricted Eating on Actigraphy-Derived Sleep Parameters

Abstract Introduction Time-restricted eating (TRE) is an emerging dietary intervention for weight loss. Sleep can be influenced by timing of food intake. Nevertheless, the impact TRE on sleep patterns remains under-explored. The Time-Restricted Intake Meals (TRIM) study was a parallel-arm, controlled feeding trial in 41 adults with obesity and prediabetes or untreated diabetes, randomized to (8am-6pm) usual pattern (UEP; 8am-12am) 12 weeks, where primary outcome change. We hypothesized that would cause changes sleep/wake patterns. Methods This post-hoc analysis TRIM using wrist actigraphy data obtained at baseline week-12. applied objective process determine parameters after estimation (Cole-Kripke) from data. analyzed 6 days/nights recordings each participant timepoint. Outcomes were duration defined mean total time per 24-hour period (TST), measured mid-sleep time, onset/offset, continuity. used paired t-tests Wilcoxon signed rank tests compare between week-12 within arms Mann-Whitney U arms. Results 38 participants (20 UEP; 18 TRE) adequate (mean age 60 years, 92% female, Black) analyzed. Baseline TST (mean□SD) 394□90 minutes 386□81 UEP TRE, respectively. Week-12 397□92 444□95 Compared UEP, increased 55 (p=0.03). shifted 44 earlier, 3:24am 2:40am (p=0.01), while maintained same 3:15am. onset median 12:22am 11:52pm (p=0.03) it remained stable (p=0.97). There no differences offset continuity Conclusion behaviors different treatment arm earlier participants. may have ancillary consequences sleep, which could clinical implications regulation. Support (if any) AHA SFRN 17SFRN33590069 K23DK133690